SYNTHESIS, ANALGESIC, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF NOVEL PYRAZOLINE DERIVATIVES.
Zakaria K. Abdel –Samii*, Hanan A. Abdel- Fattah*, Reham M. Abdel- Rehem and Hisham A. Khalifa
A series of novel pyrazoline derivatives 3a-p were synthesized via the reaction of aryl hydrazine derivatives 2a-d with chalcones 1a-d. The new compounds were screened for their analgesic, anti- inflammatory and antimicrobial activities. Compounds 3a and 3l showed a greater analgesic activity than Celecoxib. Moreover compounds 3a and 3n showed good anti-inflammatory compared to Celecoxib.However their efficacies were associated with lower gastric ulcerogenecity compared with Indomethacin.Compounds 3e and 3f showed high activities against both gram positive bacteria (Staphylococcus aureus) and gram
negative bacteria (Pseudomonas aruginosa) while compounds3e, 3k and 3 m have high activity against Candida albicans.
Keywords: Analgesic, anti-inflammatory, antimicrobial activity, synthesis, pyrazoline derivatives.
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