THE IMPACT OF THE DRUG RUTAN ON IMMUNOLOGICAL PARAMETERS IN NAFLD MODEL IN RATS
Ruzibakieva M. R.*, Ariphojaeva F. Z., Aripova T. U., Abdulajanova N.G, Batyrbekov A. A., Grigoriants K. E., Ashurova F. K. and Lubentsova O. V.
Non-alcoholic fatty liver disease includes is a liver pathologies which range from simple steatosis to non-alcoholic steatohepatitis. Polyphenols are members of a family of plant-derived compounds that can have beneficial effects on human health, and thus their study has become an increasingly important area of human nutrition research. The aim of the present study is to find the role of Rutan on immunological immunological parameters in NASH model in rats. The results reported clearly show that In liver pathology, the number of antibody-forming cells in the spleen, starting from 90 days, is significantly reduced; the total number of cells in the spleen decreases from 120 days. Under the influence of Rutan, the number of ABPC on the 30th day insignificantly increases by 21%, and on the 90-120s the stimulating activity of the drug is lost. The titer of antibodies to sheep erythrocytes in the peripheral blood of rats with liver pathology on the 90th day is significantly reduced by 22%, and on the 90th day - by 30%. Rutan does not have a significant impact on this indicator. In liver pathology, the number of cells in the thymus on the 30th day decreases by 6% (p> 0.05), on the 90th day - by 12% (p> 0.05), on the 120th day - on 16% (p> 0.05). The number of cells in the lymph nodes on the 30th day decreases by 2% (p> 0.05), on the 90th day - by 13% (p> 0.05), on the 120th day - by 15% (p > 0.05). Rutan does not affect the number of cells in the thymus and lymph nodes of rats with liver pathologies. Rutan does not affect the red and white sprout of blood formation in rats with liver pathology.
Keywords: Animal model, High-fat diet, Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis.
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