EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AN EXPERIMENTAL EVALUATION OF GASTRO PROTECTIVE EFFECT OF TRICHOSANTHES CUCUMERINA AGAINST CHRONIC ULCERS IN RATS

Anurag Kumar* and Dr. Ch. V. Rao

ABSTRACT

Background: The aim of this study was to investigate anti-ulcer activity of a vegetative fruits (Trichosanthes cucumerina) in three distinct animal models Model 1: Pylorus ligation + aspirin induced gastric ulcer model, Model 2: Acetic acid induced gastric ulcer, Model 3: Ethanol-hydrochloric acid induced gastric ulcer. Materials and Methods: Selected herbo medicinal fruits Trichosanthes cucumerina belonging to family: Cucurbitaceae. 50% ethanolic Trichosanthes cucumerina fruits extract (TCE) was used. For each experiment, animals were divided in to five groups where each group was consisting of six animals. Group were considered as Normal control, Disease control and test drug treated respectively. 50% ethanolic fruit extract was administered at a dose of 100,200,400 mg/kg/day, orally. Ulcer index, gastric wall mucus content, lipid peroxidation level in stomach tissue and tissue anti-oxidant parameters like superoxide dismutase and catalase enzyme activity were carried out for both experimental studies. Statistical calculations were done by analysis of variance (ANOVA) was performed to compare and analyse the data. Results: A dose-response antiulcer study has been done using 100, 200 and 400 mg/kg of TCE against various validated gastric ulcer models like Aspirin + Pylorus ligation induced gastric ulcer, HCl–ethanol induced ulcer and acetic acid induced gastric ulcer, gastric wall mucus content and lipid per oxidation level in comparison to normal control group whereas treatment of 50% ethanolic fruit extract (TCE), showed significant cytoprotection. The result also showed significant increase in level of antioxidant enzymes in comparison of disease control groups. Conclusion: On the basis of present data it can be concluded that 50% ethanolic fruit extract (TCE) possesses significant anti-ulcer activity against exposure to a noxious agent like NSAID, ethanol and acetic acid. The observed effect be due to synergistic anti -oxidant property of ingredients of the (TCE).

Keywords: 50% Ethanolic fruit extract (TCE), Ulcer model, anti-ulcer activity, Ranitidine.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database