FORMULATION AND EVALUATION OF TRAMADOL POROUS TABLETS

Abrar*, Patnala Ramya, Tayyaba Mahtab, Sumaiyya Saleem, P. Reena Sowmya

ABSTRACT

The present research work was aimed to develop a porous tablet of tramadol using various polymers. The formulation was optimized by using various concentrations of the disintegrants and other excipients. Menthol was used as the sublimating agent. Absorption maxima was determined to be 272nm and the calibration curve was plotted using the absorbance values of various concentration of the drug. Prior to tablet making, the formulation bled was subjected to preformulation studies which were found to be within the acceptance range indicating the powder has good flow properties. Among all the eight formulations, sixth formulation (F6) having cross carmelose in the concentration of 25mg has the highest release rate where 100.26% of the drug was release within 30 mins similar to eighth formulation but sixth formulation was considered as optimized due to low sublimating agent concentration. Moreover, FT-IR spectrum obtained showed no drug-excipient incompatibility used in preparing the formulations. Therefore, the optimized formulation F6 can be employed for scale up process as the method is simple, easy and cost effective and hence can be used during large scale production.

Keywords: Porous tablet, tramadol, absorbtion maxima, preformulation studies, post formulation studies, stability.