ANTIOXIDANT AND THROMBOLYTIC ACTIVITY OF SOUTH INDIAN DATEPALM- PHOENIX PUSILLA

Farhanaz Bh, Anuradha V.*, Suganya V. and Vijayabharathi

ABSTRACT

The present investigation was carried out to evaluate the antioxidant, free radical scavenging and thrombolytic potential of fruit and seed methanolic extract of Phoenix pusilla. The enzymatic and non-enzymatic antioxidant assays, Thrombolytic and fibrinolytic activity were also determined using in vitro methods. Inhibitions of lipid peroxidation in the egg of hen were determined using a modified method thiobarbituric acid- reactive species (TBARS) assay. The fruit pulp showed higher antioxidant activity than the seed extract which is due to the difference in the presence of phytoconstituents in them. The free radical scavenging activities of the methanol extracts of both the samples were dose dependent with all the radicals. The lysis of clot increases exponentially with time. The percentage of clot lysis produced by pulp extract is higher than the seed extract. Thus, the extracts possess considerable thrombolytic and anticoagulant activity. Such a discovery is crucial as it provides clues for potential treatment of blood coagulant disorders.

Keywords: Antioxidant, Phoenix pusilla, thrombolytic, free radicals, lipid peroxidation.