EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ANTI-MALARIAL EFFECT OF NIGELLA SATIVA SEEDS (BLACK SEED) EXTRACT ON MICE INFECTED WITH PLASMODIUM BERGEI (NK 65).

O. F. Ashcroft*, O. F. Salaudeen, K. Mohammed, T. H. I. Spencer, M. K. Garba, S. U. Nataala, M. L. Umaru and U. M. Iduh

ABSTRACT

Nigella sativa have been used for thousands of years as a curative remedy for various disorders. It is known as a source of alkaloids, tannins, saponins, cardiac glycoside, flavonoids, carbohydrate, protein, terpenoids, fixed oil, thymoquinone, thymohydroquinone, and thymol. The immeasurable medicinal properties and therapeutic uses of N.sativa prove its importance as a valuable medicinal plant. Oral administration of methanol and aqueous seed extracts (25mg/kg, 50mg/kg and 100mg/kg) of N. sativa were screened in the 4-day suppressive assays for their anti-malarial properties against Plasmodium bergei in mice. The oral treatment of the seed extracts showed suppression activities in all groups of mice which significantly (p<0.05) decreased the parasitaemia. The results of this study reveals the antimalarial properties of this extracts, shows a correlation between anemia and malaria and open a new opportunity to further investigate the potentials of new plant based antimalarials in the future. However, the exact principles for this antimalarial action are yet to be identified, which need further studies to elucidate the antimalarial mechanism of their action.

Keywords: Malaria, Plasmodium bergei, Nigella sativa.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia