EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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 ICV - 79.57

Abstract

BIOLOGICAL ACTIVITY OF BARTOGENIC ACID GLUCOSYL HEXAACETATE ISOLATED FROM COMBRETUM MICRANTHUM ON PLASMA RECALCIFICATION TIME OF NAJA KATIENSIS AND BITIS ARIETANS VENOMS

*Abdullahi Balarabe Sallau, Habib Umar DanMalan, Abdullahi AbdulMalik Salman, Yusuf Tauhid, Yusuf Opemile

ABSTRACT

Biological effect of bartogenic acid 28-β-D-glucosyl hexaacetate (BA), a triterpenoid, isolated from the root of Combretum micranthum on recalcification time of bovine plasma treated with Naja katiensis and Bitis arietans venoms was investigated. The plasma recalcification time (PRT) was found to be effectively reduced in a dose dependent fashion. Inhibition of 73.2 % at 1 mg/ml BA on the elongation of the PRT by N. katiensis venom was obtained. This was however found to decrease to a low level of 5.4 % when 0.001 mg/ml of BA was used. Similarly, the highest and lowest inhibition values of 47.7 % and 28.6 % at 1 mg/ml and 0.001 mg/ml doses of BA on the elongation of the PRT by B. arietans venom were obtained respectively. This study showed that BA could effectively serve as an inhibitor of snake venom induced bleeding, as it was shown to quantitatively reduce the plasma recalcification time.

Keywords: Triterpenoid, plasma, inhibitor, venom, recalcification time.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia