( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Elleuch Nour, Sonda Jardak, Dahmani Wafa, Jaziri Hanene, Aida Ben Slama, Aya Hammami, Salem Ajmi, Braham Ahlem, Ksiaa Mehdi and Jmaa Ali


Introduction: Eosinophilic gastrointestinal disorders (EGD) are rare chronic digestive pathologies characterized by an eosinophilic infiltration of the digestive tract in the absence of secondary causes for eosinophilia. Their diagnosis reprensents a real challenge to clinicians because of aspecific clinical features. Objective: to analyze the clinical, biological, radiological characteristics of EGD as well as the endoscopic, histological and therapeutic features of these disorders through to the experience of a Tunisian center. Methods: a retrospective study from 2006 to 2017 including patients diagnosed with EGD based on three criteria: Suspicious clinical symptoms, histologic evidence of eosinophilic infiltration in the bowel and exclusion of other pathologies with similar findings. Results: A total of 16 cases of EGD were collected, divided into eosinophilic esophagitis (9 patients), eosinophilic gastroenteritis (3 patients) and eosinophilic colitis (4 patients). Mean age was 36.8 (12-52 years). The sex ratio was 1.66 (M/F=10/6). More than half of patients had a personal history of atopic disease (n=9). Symptoms were non-specific and various: dysphagia (n=7), diarrhea (n=3), abdomianl pain (n=3), vomiting (n=2) and ascitis (n=1). The third of patients had increased numbers of circulating eosinophils. Total IgE levels were increased in 37.5% of patients (n=6). The definitive diagnosis was based on histological results : tissue obtained during upper gastro intestinal endoscopy (n=11), colonoscopy (n=4) and laparoscopy (n=1). The treatment was based on corticosteroids (n=9), proton pump inhibitor (n=4), salicylates (n=2) and dietary therapy (n=1). Conclusion: EGD are uncommon and heterogeneous diseases. Up to now, many problems still left to be answered. In the future, large and high-quality studies are needed to further investigate the pathophysiology of EGD and to make standard guidelines for the diagnosis and management.

Keywords: Eosinophilic esophagitis, Eosinophilic gastroenteritis, Diagnosis, Therapy.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database