EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF MICROCAPSULES SOLID DISPERSION OF METFORMIN HCl ORAL ADMINISTERED FORMULATION ON HYPERGLYCEMIA IN RATS

Mona I. El-Assal*, Ahmed Abdel Bari and Mohamed Rafat

ABSTRACT

The present study is to examine In-vivo pharmacodynamics antidiabetic effect following oral administration of the selected optimized microcapsules in comparison with oral metformin solution. Solid dispersions microcapsules were prepared using solvent evaporation method which enclosed preparation of a uniform dispersion of Metformin HCl in (Hydroxy propyl methylcellulose k100, Ethyl cellulose, Eudragit RL PO, Eudragit RS PO and Compritol 888 ATO). A two-factor, General factorial statistical design was used to quantitate the effect of polymer type(X1) and drug: polymer ratio(X2) on the release profile. Where polymer type and drug: polymer ratio were selected as independent variables, while Y1 (cumulative drug release after 1 h) and Y2 (cumulative drug release in 3 h), Y3 (cumulative drug release in10 h),Y4 (angle of repose ) and Y5(Hausner ratio) were selected as dependent variables. A convenient statistical model was made and a significantly controlled release rate was exhibited. The solid dispersions were characterized for their in vitro- release rate. The oral administration of formulae (T20) which consists of metformin HCl and compritol 888 ATO) in drug/polymer ratio (1:4) was chosen as optimum formula resulted in a clear long lasting Statistically significant anti-hyperglycemic effect up to 12 h as compared to diabetic control Group and metformin HCl solution treated group. Factorial design suggested only one optimized combination of the polymer by which maximum desirability obtained. The oral administration of formulae (T20) resulted in a clear long lasting statistically significant anti-hyperglycemic effect.

Keywords: Controlled release, Factorial design, In-vivo study, Metformin HCl, Solid dispersion.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )