EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

INFLAMMATORY BREAST CANCER IN A TUNISIAN UNIVERSITY HOSPITAL FROM 2007 TO 2012 : HOW TO MANAGE INFLAMMATORY BREAST CANCER WITH LIMITED RESSOURCES

Ammar.N¹, Ezzaairi.F, Belaid.I, Khechine.W, Ben fredj.M, Zaghouani.H, Hochlaf.M, Chabchoub.I, Ben fatma.L, Mokni.M4, Bibi.M, Ben ahmed S

ABSTRACT

IBC is the most aggressive and deadly form of breast cancer and is frequently misdiagnosed and therefore considered as a rare entity. The typical clinical presentation of a quickly developing locally advanced disease shows the obvious limitations to the early diagnosis of the disease with radiological screening approaches. Management involves coordination of multidisciplinarymanagement. This multimodal therapeutic approach has significantly improved patient survival. Objectives: assess the clinical-pathological parameters and outcome of IBC at the center of Tunisia. Materials and Methods: We screened 1260 breast cancer cases registered from January 2007 to December 2012 and found100 cases of IBC. Patients who presented with IBC as a recurrence, or who had a neglected and advanced breast cancer that simulated an IBC were excluded from this study. Results: The median age was 51 years (range 29-85). The median duration of symptoms was 4 months. The American Joint Committee on Cancer stage (AJCC) distribution was Stage III- 57 and IV- 43 patients. Estrogen receptor (ER), progesterone receptor (PR) positivity and human epidermal growth factor receptor2 (HER2/neu) positivity were 57%, 46% and 36 %, respectively. Triple negativity was found in 35% of the cases. All the non metastatic IBC patients received anthracycline and/ or taxane based chemotherapy followed by modified radical mastectomy, radiotherapy and hormonal therapy as indicated. The pathological complete remission rate was 21 %. At a median follow-up of 149 months, the 3 year relapse free survival and overall survival were 15% and 28 % respectively. Median overall survival was 18 months, and its influencing factors according to our results were: estrogen receptor positivity, presence of extracapsular extension and M tumor stages, lymphovascular space invasion and adjuvant chemotherapy. Conclusion: IBC is an aggressive subtype of locally advanced breast cancer; it is heterogeneous with various factors influencing survival.

Keywords: Inflammatory breast cancer – Epidemiology- treatment - outcome –prognostic factors- Tunisia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia