EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EXPERIMENTAL ACETIC ACID-INDUCED COLITIS IMPAIRS FERTILITY INDICES THROUGH DISRUPTED HORMONAL FEEDBACK IN MALE RATS

Serah Funke Ige*, Mayowa Jeremiah Adeniyi, Jelili A. Badmus and Suliyat Aremu

ABSTRACT

Although, men with ulcerative colitis demonstrate more infertility tendency than their healthy counterparts, the mechanisms through which colitis impairs fertility are not well understood. Therefore, the study investigated whether colitis associated impairments in fertility indices are characterized by intact or disrupted hormonal feedback. 12 male rats aged 53 days were randomly divided into control and colitic groups. Colitis was induced through intrarectal instillation of 1ml/200g of 7% acetic acid 5 times at an interval of 7 days. 72 hours after the fifth induction, colitic rats were characterized by increases in colonic thickness, colonic weight and rectal temperature. When compared with control group, colitic group exhibited a significant decrease (P<0.05) in sperm count, sperm motility, sperm morphology, testicular weight and percentage body weight change. Colitis significantly disrupted pituitary Follicle Stimulating Hormone (FSH) secretion but had no effect on luteinizing hormone. There was also a reduction in steroidogenic capacity of testes evidenced by significant decrease (P<0.05) in serum testosterone. The findings of this study indicated that colitis decreased fertility indices in male rats through disrupted hormonal feedback.

Keywords: Infertility, Follicle Stimulating Hormone, Luteinizing Hormone, Colitis, Sperm count.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )