EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF ANTIULCER ACTIVITY IN CANNA INDICA RHIZOMES

Mallikarjun Bere*, Rajesh Miryala, Srikanth Lingala, Chandramouli Golla and Naveen Chandra Kotagiri

ABSTRACT

With the rapid progress and advancement in various fields of human activities, the field of medicine and allied sciences has also made rapid strides. The synthesis of many chemicals and their introduction into therapeutics as drugs has certainly revolutionized the treatment of diseases. Peptic ulcer disease is a serious gastrointestinal disorder that requires a well targeted therapeutic strategy. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapses, side effects and drug interactions. In an attempt to search a potent and safe medication for peptic ulcer, Canna indica rhizomes is being screened for its anti ulcer activity. Canna indica rhizomes were collected in Toopranpet village of Nalgonda district. Methanolic extraction method was used for extracting the active chemical constituents from plant materials. Acute toxicity study was carried out in male Swiss albino mice. MECI are considered to be safe up to the dose levels of 1000 mg/kg (b.w). By Asprin induced ulcer method, the standard drug of ranitidine showed 48.32% of ulcer inhibition. The % inhibition of 100 mg/kg, 200 mg/kg, and 400 mg/kg values are 19.35, 23.61, and 43.89 respectively. By Pyloric ligation induced ulcer method, the standard drug of ranitidine showed 79.23% of ulcer inhibition. The % inhibition of 100 mg/kg, 200 mg/kg, and 400 mg/kg values are 28.3, 53.46 and 65.45 respectively.

Keywords: Canna indica, Indian shot, Rhizomes Peptic ulcer and Herbal drugs.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )