EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF OCIMUM SANCTUM (TULSI) LEAF IN WISTAR ALBINO RATS AFTER SUB-ACUTE ADMINISTRATION

Sumina S., Kingshuk Lahon*, Johan Pandian, Manimekalai K.

ABSTRACT

Background: Drugs for anxiety have adverse effects causing decreased compliance with treatment. Hence there is potential for plant based alternatives with fewer adverse effects which are used in traditional medicine, like Ocimum sanctum. Aim: To evaluate the anxiolytic activity of ethanolic leaf extract of Ocimum sanctum after subacute administration. Materials and Methods: 24 wistar albino rats of either sex were divided randomly into four groups (n=6) and administered normal saline, Ocimum sanctum ethanolic extract (OSEE), Alprazolam and OSEE + half dose Alprazolam respectively for 30 days. Elevated plus maze and Light and Dark Arena tests for anxiety were carried out on days 1, 7, 15 and 30. Results were expressed as Mean ± SEM. One way ANOVA (P<0.05 regarded as significant at 95% Confidence Interval), followed by Tukey’s post hoc test were used for statistical analysis. Results: Animals receiving OSEE and OSEE + half dose alprazolam demonstrated significant anxiolytic effect by increasing the time spent in open arms/ light area and the number of entries in open arms/ light area in the Elevated Plus Maze model and Light and Dark arena model respectively. The combination showed anxiolytic effect which was comparable to that of full dose of alprazolam/fluoxetine. Conclusion: OSEE alone and its combination with half dose standard drug alprazolam showed significant anxiolytic activity with the combination showing activity comparable to that of full dose standard drug.

Keywords: Sub-acute, Anxiolytic, Ocimum sanctum, Albino Rats.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )