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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Kalpana Divekar*, Murugan Vedigounder, Anita Kurup and Rama Sharma


Oxadiazole have often been described as bio-isosters for amide & esters. Due to increased hydrolytic & metabolic stability of oxadiazole ring an improved, pharmacokinetic and in-vivo performance is often observed, which makes these heterocyclic ring as an important structural motif for the pharmaceutical Industry. Due to these characteristics oxadiazoles have impacted numerous areas of drug discovery like muscarinic antagonists, benzodiazepines receptor partial agonists, dopamine transporters, antirhinovirals, growth hormone secretagogues, 5-HT antagonists, antispasmodics, nematocidals, fungicidal & microbicides, analgesics, anti- inflammatory, anticonvulsant, antibacterial, immunosuppressants, antiplatelet & antithrombics. In the present work, an attempt was made to synthesize some novel oxadiazole derivatives by converting the Aromatic carboxylic acids into acid esters by conventional esterification. The esters obtained were treated with hydrazine hydrate to give aromatic hydrazides. Those hydrazides on refluxing with carbon di sulfide in presence of potassium hydroxide yielded different oxadiazole derivatives. Then those oxadiazole derivatives were subjected to acetylation and aromatic group attachment. The synthesized compounds were characterized and confirmed by IR and 1HNMR spectroscopy and then screened for anticonvulsant activity. The anticonvulsant activity of newly synthesized oxadiazole derivatives was carried out by maximal electro-shock-induced convulsion method (MES) using ear electrodes in mice. Diazepam was used as positive control and normal saline served as solvent control. The investigation revealed that out of twelve newly synthesized derivatives six were found to possess anticonvulsant activity.

Keywords: Bioisosters, oxadiazoles, anticonvulsants.

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  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 June 2024 Issue has been Published, Kindly check it on


    JUNE 2024 issue has been successfully launched on JUNE 2024.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia