EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ERENUMAB-AOOE: PROMISING MONOCLONAL-ANTIBODY FOR PROPHYLAXIS OF MIGRAINE IN ADULTS

Ranjodh Jeet Singh and Kanika Kohli*

ABSTRACT

Introduction: Migraine is one form of disorder affecting the quality of life of patient and disabled brain disorder. The term chronic migraine refers to a clinical condition summarized by migranous headache on fifteen days usually per monthly episode. Most commonly patients on pharmacotherapy of migraine include Ergot derivatives, Triptans, Opioids, and Analgesics for a period range of ten days per month. Even though the pathology and physiology of migraine is not fully understood and established, but however several other risk factors which are associated as triggers of migraine are considered to deal with. The CGRP is involved in pathology and physiology of origin of neurovascular headaches viz migraine at both peripheral and central levels. The CGRP is highly expressed in trigeminal neurons (small myelinated Ad and unmyelinated C fibers) co-localized with other neuropeptides (e.g., substance P). The CGRP levels are increased into external jugular venous blood ipsilateral to pain during headache phase of migraine attack with or without aura. Also the saliva and serum CGRP levels are increased during migraine and interictally in patients with CM. Thus CGRP monoclonal antibodies are considered to target smooth muscle cells on blood vessels and glial cells and neurons located outside BBB, probably in brainstem paraventicular structures and trigeminal ganglion. Scope: Erenumab-aooe, CGRPr antagonist, being the latest approved drug administered via subcutaneous route as 70 mg per month for prophylactic regime of migraine in adult patients, the results documented as per clinical trials data are very promising and thus Erenumab-aooe is an emerging hope to improve the quality of life and make the patients able to perform their life activity with effectiveness. Conclusion: Chronic migraine is not fully treated as the pharmacotherapy response is at the poor level and also limited pharmacotherapy is available, however the emergence of Erenumab-aooe, CGRPr antagonist as the one of the latest drug approval for the prophylaxis of migraine in adults is by far the greatest scope for the better treatment module of migraine.

Keywords: CM: chronic migraine, EM: episodic migraine, LSM: least square mean, MMD: monthly migraine days, ICHD: International classification of headache disorders, CGRPr: Calcitonin gene related peptide receptor, MHD: monthly headache days.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia