DESIGN AND EVALUATION OF PRESS COATED PULSATILE DELIVERY OF DOXOFYLLINE TABLETS
Golla Chandra Mouli*, Dr. B. Agaiah Goud, J. Subhash, B. Mallikarjun and Dr. L. Srikanth
The objective of this work was to develop and evaluate a pulsatile drug delivery system intended for chronopharmacotherapy. The press-coated tablet (PCT) containing doxofylline in the inner core was formulated with an outer barrier layer by different compositions of hydrophilic polymer hydroxyl propyl methyl cellulose (HPMC E50) and hydrophobic polymer ethyl cellulose. The effect of formulation composition on the barrier layer comprising both hydrophilic and hydrophobic Polymers on the lag time of drug release was investigated. Among different barrier compositions from (F1 –F3), F3 was found to show single pulse drug delivery with considerable drug release for 6hrs after maintaining the pre expected 6hrs lag time.
Keywords: Pulsatile drug delivery; Press-coated; Lagtime; Doxofylline; HPMC; Ethyl cellulose.
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