SAFETY OF ORAL CHOLERA VACCINES IN PREGNANCY:A REVIEW
*Bincy Baby, Shary Ramesh, Nirajana Shyam, Athira R S and Ann Mariam Varghese
ABSTRACT
Cholera is a rapidly dehydrating diarrhoeal disease caused by ingestion of toxigenic serogroups of Vibrio cholerae. Cholera in pregnancy is associated with serious complication leading to fetal loss in 2-36% cases. Safety evaluations done in pregnant women during cholera outbreaks suggest that OCV’S are safe during pregnancy. WHO recommend killed whole celled vaccines to reduce the risk of cholera which include Dukoral and Shancol. According to the 2010 WHO Position Paper on cholera vaccines, mention pregnant women as a group that is “especially vulnerable to severe disease and for which the vaccines are not contraindicatedâ€, and thus a possible target for vaccination as well. Use of OCV’S in pregnancy is associated with many risk and benefits. Based on the analysis of risk and benefit, there are considerable benefits and very few risks from including pregnant women in vaccine campaign.
Keywords: Vibrio cholera, Dukoral and Shancol.
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