STUDY OF THE STATE OF THE IMMUNORAACTIVITY OF THE ORGANISM OF CHILDREN WITH A NASOPHARYNGEAL CANCER

*Polatova D. S., Karimova N. M., Ismailova A. A., Hayitov F. E., Iskandarova I. M., Nuriddinov K. R., Boboev M. M., Hayitova A. T. and Abdukhakimova M.

ABSTRACT

The purpose of this work was to study the state of immunoreactivity in children with nasopharyngeal cancer. Proceeding from the received results it is visible, that at a cancer of a nasopharynx at children the expressed unbalance cellular and humoral parts of immune system is observed. Imbalance in the cellular immunity unit was expressed in the suppression of the immunoregulatory index due to a decrease in the number of T-helpers / inducers and an increase in T-cytotoxic lymphocytes. Circulating immune complexes of large and small values were increased. Consequently, the role of immunological factors in the formation and flow of nasopharyngeal cancer in children is indicated by various changes in the state of immunoreactivity. Obviously, the T-cell response is much weaker and is directed against a smaller number of tumor epitopes, which suggests that clonal depletion of T-lymphocytes is possible against the background of activation of some humoral immunity factors.

Keywords: Nasopharyngeal cancer in children, adaptive immune response, lymphocytes, cellular immunity factors, immunoglobulins.