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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Ramazan Ilyas Oner*


Significance: Retina is considered to be an easily traceable part of the brain. Even though the retina does not contain myelin, it is an ideal model of neuronal tissue where degeneration of the ganglion cell neurons and their associated axons may occur. Purpose: We aimed at examining ganglion cell complex structures such as the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) by Optical Coherence Tomography (OCT), determining whether inflammatory factors caused damage to the retinal neuronal network in patients with Behçet’s disease (BD) who did not show optic atrophy, i.e., did not develop chronic retinal vascular ischemia. Methods: Forty-two patients with BD and 42 healthy volunteers were included in the study, and their eye RNFL, GCL, and IPL thicknesses were measured using OCT. Results: It was determined that there was a significant decrease in both GCL and IPL thicknesses in patients with BD when compared with those in control patients. There was a statistically significant negative correlation between C-reactive protein levels and GCL and IPL thicknesses. There was a negative correlation between C-reactive protein (CRP), GCL, and IPL, which was statistically significant (r = −0.36 and P = .001 between GCL and CRP and r = −0.22 and P = .039 between IPL and CRP). Conclusion: In patients with BD without optic nerve involvement who did not develop optic atrophy, degeneration was detected in some layers of the retinal nerve network (GCL and IPL), suggesting that this degeneration develops before the possible vascular endothelial damage in the optic nerve. Therefore, performing a retinal nerve follow-up using OCT in the early stages of BD may be an important aspect in monitoring the progression of the disease.

Keywords: Behçet’s disease; Optical Coherence Tomography; Retinal nerve degeneration.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )