EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

HONEY IN THE TREATMENT OF PERSISTENT CHRONIC OTITIS EXTERNA; A RANDOMIZED PLACEBO-CONTROLLED TRIAL

Mohamed G. Hamed*, Naslshah G. Kazem, Hamada F. Hashem, Taha M. Abdel Aal and Ola G. Kazem

ABSTRACT

Background: The current study aimed to determine the efficacy and safety of honey in the treatment of persistent chronic otitis externa. Patients and methods: This randomized-controlled study was conducted in Helwan and Banha Medical Universities Hospitals, Egypt in the period 2014-2016. Eligible patients were randomly allocated to the study group and the control group. For the study group, Honey ear drops 1 ml was used, and for the control group undiluted glycerol was used. The primary outcome measure was the number of organisms in tenfold diluted broth culture in after the treatment period. Results: A Hundred patients were included in the analysis, 50 in each group. The two groups were comparable regarding the baseline characteristics. At the end of the study, there was a highly significant difference in the number of organisms in tenfold diluted broth culture between groups (p-value < 0.001) where it was 34.28(9.37) & 58.98 (11.44) in the Honey groups and the Placebo group, respectively. Moreover, improvements in patients’ symptoms (discomfort, itchiness, wetness, and smell) were significantly higher in the Honey group than in the Placebo group. Also, improvements of signs (erythema, ulceration, granulation and discharge quantity) were significantly higher in the Honey group than in the Placebo group. There were no adverse events for the Honey drops. Conclusions: Honey is effective as ear drops for persistent chronic otitis externa.

Keywords: Honey; ear drops; persistent otitis externa; otorrhea.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia