EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SEROPREVALENCE OF TOXOPLASMA GONDII IGG AND IGM ANTIBODIES IN A HEALTHY FEMALE POPULATION FROM DELHI.

Poonam Gupta, *Manoj Jais, Sanjib Gogoi, Suraiya K Ansari

ABSTRACT

Introduction: Toxoplasma gondii infection can cause congenital abnormalities, and even fetal loss. In India, awareness about TORCH group of infections cause congenital conditions is poor and routine testing is not recommended by obstetricians but is recommended to those who have had an undesirable pregnancy outcome. Aim: To evaluate the seroprevalence of IgM and IgG antibody of toxoplasma among the healthy female population in Delhi. Methodology: The study was done in Lady Hardinge Medical College, New Delhi. A total of 1000 serum samples were taken over a period of two years from apparently healthy female population. 500 samples were included from healthy ANC females whose samples had come for routine VDRL screening and 500 were apparently of healthy female children 5 -15 years (Average 11) whose ASO and CRP were negative over a period of two years. All the samples were subjected to ELISA test for detection of IgM & IgG antibodies. Results:A total of 1000 participants consisting of ANC females and children (5-15 years), 500 each were included in the study. Out of 1000 samples tested for IgM and IgG antibodies, 766 (76.6%) were negative and 234 (23.4%) were positive for Toxoplasma antibodies. Conclusion: Overall positivity rate of IgM, IgG and both were found to be 59 (5.9%), 122 (12.2%), 53 (5.3%) respectively. The positivity rate of IgM, IgG & both among adult female was 32 (6.4%), 82 (16.4%), and 32 (6.4%) respectively whereas in female children it was 27 (4.4%), 40 (8.0%), 21 (4.2%) Overall seropositivity rate of IgG antibody among children and adult was found to be statistically significant (p < 0.05, chi square) which indicated that incidence of toxoplasmosis increases with age. At the same time no significant difference was found in the two groups in IgM and both IgM and IgG positivity. This indicated that both children and adults are at equal risk of infection with Toxoplasma gondii.

Keywords: Toxoplasma gondii, seroprevalence females, IgG, IgM, Delhi.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia