EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

SYNTHESIS OF SOME NOVEL HETEROCYCLIC COMPOUNDS CONTAINING PHTHALAZINE OR 1- OXOPHTHALAZINE MOIETY WITH EXPECTED BIOLOGICAL ACTIVITY

M. A. Hawata, A. H. Abdel-Aleem*, A. A. Assar and E. F. Abd Elmaqsoud

ABSTRACT

Synthesis of new series of phthalazine derivatives starting from phthalic anhydride 1 with benzene or chlorobenzene in the presence of AlCl3 anhydrous afforded 2(a,b), further cyclisation with hydrazine hydrate afforded 3(a,b), by chlorination with POCl3 in DMF gave 4(a,b), phthalazine derivatives 5,6(a-c) were formed by reaction 4(a,b) with aromatic amines. On the reaction of 3(a,b) with chlorosulphonic acid with excess of thionyl chloride at 0°C to afforded 7(a,b) which reacted with hydrazine hydrate afforded 8(a,b), phthlazine sulphonylhydrazone derivatives 9,10(a-d) and 11,12(a-c) were formed by reaction 8(a,b) with aromatic aldehydes or sugar aldehydes. On the reaction 3(a,b) with phenylisocyanate or phenylisothiocyanate in benzene afforded 13,14(a,b), according to Mannich condition 15(a,b) were formed by reaction 3(a,b) with pipredine and formaldehyde solution and one drop HCl were refluxed in ethanol. The structures of the synthesized compounds were confirmed by IR, Mass spectra, 1HNMR and 13C NMR spectral data. The biological activities of synthesized compounds were studied.

Keywords: Phthalic anhydride, phthalazine derivatives, phthlazine sulphonylhydrazone, biological activity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )