EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

SYNTHESIS AND CHARACTERIZATION OF MURVA ENCAPSULATED CHITOSAN NANOPARTICLES FOR THE TREATMENT OF DIABETES MELLITUS

N. Arulanandraj*, Dr. V. Gopal, S. Dhivya and Dr. G. Jayabalan

ABSTRACT

Design and development of herbal novel drug delivery system has become a frontier research in the novel drug delivery system arena. Murva is a potent phytomolecule obtained from Maerua oblongifolia of family capparaceae, has been traditionally used to cure various diseases. The limitations of herbal drugs are poor biodistribution and instability. In order to improve the therapeutic efficacy and stability, the herbal drug Murva was encapsulated in chitosan nanoparticles. Chitosan nanoparticles containing Murva (CNP1-CNP5) were synthesized by ionic gelation of chitosan with tripolyphosphate anions (TPP) resulting in particles size smaller than 650nm. The encapsulation efficiency of nanoformulations was over 41.5%. The nanoformulations exhibited slow and sustained in vitro release over 99% of drug from the Murva encapsulated chitosan nanoparticles after 24 hours. The synthesized nanoformulations were found to be stable, biocompatible and produced an enhancement of anti-diabetic activity.

Keywords: Chitosan, Tripolyphosphate, Nanoparticles, Murva.

[Full Text Article] [Download Certificate]