SYNTHESIS AND CHARACTERIZATION OF MURVA ENCAPSULATED CHITOSAN NANOPARTICLES FOR THE TREATMENT OF DIABETES MELLITUS
N. Arulanandraj*, Dr. V. Gopal, S. Dhivya and Dr. G. Jayabalan
Design and development of herbal novel drug delivery system has become a frontier research in the novel drug delivery system arena. Murva is a potent phytomolecule obtained from Maerua oblongifolia of family capparaceae, has been traditionally used to cure various diseases. The limitations of herbal drugs are poor biodistribution and instability. In order to improve the therapeutic efficacy and stability, the herbal drug Murva was encapsulated in chitosan nanoparticles. Chitosan nanoparticles containing Murva (CNP1-CNP5) were synthesized by ionic gelation of chitosan with tripolyphosphate anions (TPP) resulting in particles size smaller than 650nm. The encapsulation efficiency of nanoformulations was over 41.5%. The nanoformulations exhibited slow and sustained in vitro release over 99% of drug from the Murva encapsulated chitosan nanoparticles after 24 hours. The synthesized nanoformulations were found to be stable, biocompatible and produced an enhancement of anti-diabetic activity.
Keywords: Chitosan, Tripolyphosphate, Nanoparticles, Murva.
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