EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A REVIEW ON PARKINSON’S DISEASE

Soumya R. V.*, Babitha M., Nithin Manohar R., Neethu J., Jisha Vijayan, Sruthy S. A.

ABSTRACT

Parkinson’s disease (PD) is the most common neurodegenerative disorders characterized by a neuronal accumulation of the presynaptic protein synuclein and by variable degrees of parkinsonism, defined as a paucity and slowness of movement (bradykinesia), tremor at rest, rigidity, shuffling gait, and flexed posture. Nearly all forms of parkinsonism result from a reduction of dopaminergic transmission within the basal ganglia. . The incidence of PD is between 8 and 18 per 100,000 person in years. Prevalence in India is ab70/100,000 population and this is lower than that reported in the West. Most PD cases occur sporadically and of unknown cause. Twin studies suggest that environmental factors likely play the more important role in patient older than 50 years, with genetic factors being more important in younger patients. In PD dopaminergic and other cells die due to a combination of factors including: Genetic vulnerability, Oxidative stress, Proteosomal dysfunction, Environmental factors. Many risk factors and protective factors have been proposed, sometimes in relation to theories concerning possible mechanisms of the disease. None have been conclusively related to Parkinson’s disease by empirical evidence. Therapy in PD are to maintain function and quality of life and to avoid drug-induced complications. This is obtained through the use of drugs that either increase dopaminergic actions or diminish neuronal outflow from the striatum.

Keywords: PD, signs and symptoms, pathogenesis, treatment.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )