DEMOGRAPHIC STUDY OF CHRONIC MYELOID LEUKEMIA IN NEAPLESE POPULATION IN EASTERN NEPAL

Presha Baral*, Samjhana Shrama and Tripti Shakya

ABSTRACT

Background: Chronic Myeloid leukemia is a clonal myeloproliferative disorder of the primitive hematopoietic stem cell. CML is characterized by the presence of chromosomal marker the Philadelphia chromosome (Ph) in the leukemic cell. Although patients can be of all age group it is usually common in adulthood. Male population is more commonly affected than female population. The study aims to identify the CML by detection of Philadelphia Chromosome and study the demographic pattern in the Nepalese Population. Method: Thirty cases of Chronic Myeloid leukemia which were diagnosed clinically were randomly selected for study. Bone marrow samples were collected in heparinized vials. Cytogenetic analysis was done by karyotyping. Philadelphia Positive and negative case were identified. Hematological parameters were noted and correlated with features of CML. Results: Out of thirty diagnosed case of Chronic Myeloid leukemia 23 were male and 7 were female. The male female ratio was 3.29:1. The age of disease presentation varied from 16 – 68 years with highest number of patient observed in age group 20-29. Conclusion: Although CML can occur at any age group, it was observed that in this study the incidence was more in early adulthood. Small sample size is the limitation in this study to establish the exact age of incidence in eastern Nepal.

Keywords: CML, demography, Nepalese population.