EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

THE EFFECTS OF RESVERATROL AND SULFORAPHANE ON THE REGULATION OF INOS/NRF2 PATHS IN THE OROFACIAL INFLAMMATION-INDUCED MODEL

Min-Kyoung Park, Min-Kyung Lee and Kyung-Yae Hyun*

ABSTRACT

This study aimed to identify the effect of resveratrol and sulforaphane on the regulation of inflammation in the orofacial inflammation-induced model. Orofacial inflammation was induced by injecting 5% formalin (50 μl) under the skin of the right side of the face of rats using an insulin syringe. Resveratrol and sulforaphane were found to suppress the secretion of IL-6 or IL-1β and regulate the expression of Nrf2 (or NFE2L2: Nuclear factor (erythroid-derived 2)-like 2), iNOS (inducible nitric oxide synthases) or Nox4 (NADPH oxidase 4). Resveratrol and sulforaphane seem to regulate pro-inflammatory cytokines (IL-6 or IL-1β) and iNOS/Nrf2, and thus to reduce and protect against orofacial inflammation.

Keywords: Resveratrol, Sulforaphane, Cytokine, iNOS, Nrf2.

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SJIF Impact Factor: 7.065

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Its Our pleasure to inform you that, EJPMR 1 September 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue