THE STUDY OF HISTOLOGICAL PARAMETERS IN THE DEVELOPMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE IN RATS
Ruzibakieva M. R.*, Ariphojaeva F. Z., Aripova T. U., Batyrbekov A. A., Grigoriants K. E., Ashurova F. K., Sharakhmedova M. and Lubentsova O. V.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease over the world, and it persists at a high prevalence. NAFLD is characterized by a spectrum of histopathological findings, ranging from simple fatty liver through non-alcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis, which may progress to hepatocellular carcinoma. Understanding the pathophysiology and treatment of NAFLD in humans has currently been limited by the lack of satisfactory animal models. The ideal animal model for NAFLD should reflect all aspects of the intricate etiopathogenesis of human NAFLD and the typical histological findings of its different stages. The choice of a suitable animal model for this disease while respecting its limitations may help to improve the understanding of its complex pathogenesis and to discover appropriate therapeutic strategies.
Keywords: Animal Model, High-Fat Diet, Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis.
[Full Text Article]