( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Zain Amar*, Sanober Jamali, Saad Abdul Quddus, Burhan Memon and Hiba Jamali


Objective: To analyze serum homocysteine and vitamin B12 in type 2 diabetics taking metformin therapy. Study Design: Cross sectional study design. Study setting & Duration: Department of Medicine, Liaquat University Hospital Jamshoro/Hyderabad from august 2017 to March 2018. Subjects and Methods: A sample of 100 volunteers; 50 controls (type 2 diabetics) and 50 cases (type 2 diabetics taking metformin), was selected according to selection criteria. Venous blood samples were collected under aseptic conditions. Random blood glucose, glycated Hb A (HbA1c), serum homocysteine and vitamin B12 were detected. Data was analyzed on SPSS ver 22.0 (IBM, Incorporation, USA) at 95% Confidence interval (P ≤ 0.05). Results: Elevated serum homocysteine was noted 48% in cases compared to 6% in controls (P=0.0001). Vitamin B12 deficiency in controls was noted as 38% versus 64% in cases taking metformin therapy (P=0.0001). Serum homocysteine and Vitamin B12 in controls and cases was noted as 6.71±2.82 μM/L and 15.35±11.97 μM/L & 239.54±61.72 pg/dl and 197.40±76.23 pg/dl respectively (P=0.0001). Vitamin B12 shows negative correlation of vitamin B12 with serum homocysteine (r= -0.629, P= 0.0001). Conclusion: The present study reports vitamin B12 deficiency in 64% and elevated homocysteine in 48% type 2 diabetics taking metformin therapy.

Keywords: Homocysteine, Vitamin B12, Metformin, Type 2 Diabetics.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database