EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PREPARATION AND STUDY OF EFAVIRENZ MICROEMULSION DRUG DELIVERY SYSTEM FOR ENHANCEMENT OF BIOAVAILABILITY

Hemal Tandel*, Pratiksh Patel, Parva Jani

ABSTRACT

The purpose of study was to develop a microemulsion drug delivery system to enhance the bioavailability of Efavirenz(EFV). The microemulsion was prepared using efavirenz(drug), Capryol 90(oil), Tween 20 and Cremophor EL(surfactant) and Transcutol HP (co-surfactant) and water. The optimized formula for microemulsion was determined using phase diagrams which were constructed prior to the formulation. The physical evaluation like globule size, zeta potential, pH, conductance, drug content, stability etc. were performed along with in vitro and ex vivo studies. The pharmacokinetics studies were
also performed on male albino rat. The optimized formulation of efavirenz microemulsion had globule size and zeta potential of was found to be 15.8±0.71nm and -12.6±0.23mv respectively. The optimized formulation showed higher drug release in in vitro and ex vivo studies as compared to pure drug suspension. Efavirenz microemusion shows 1.88 folds increase in peak plasma concentration in comparison to pure drug suspension and AUC was found to increase 2.15 fold in comparison to pure drug suspension. The size reduction by microemulsion would improve the bioavailability of the drug in vivo after oral administration.

Keywords: Microemulsion, Efavirenz, Pharmacokinetic, Bioavailability.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )