WHAT ?S EFFECT?VENESS ON THE HEART OF DRUGS USED ?N ALZHE?MER’S D?SEASE?
Hasan Ata Bolayir* and Asli Bolayir
Objective: The aim of this study was to retrospectively determine the Emergency or Cardiology department admission rates with cardiac complaints of the patients with Alzheimer’s disease(AD) and establish whether these rates changed between the patients who used acetylcholinesterase inhibitors (AchEI) and those who did not. Materials and Methods: This single-centered retrospective study included 605 patients who were diagnosed with AD between January 2010 and 2018. The patient group was separated to two subgroups according to the use of AChEIs. Results: Comparison of these two subgroups in terms of baseline demographic and clinical characteristics demonstrated that there was no significant difference between them(p>0.05). When these two groups were compared in terms of the ratio of myocardial infarction, angina pectoris, bradycardia, hypotension or serious arrhythmia identicated that there was no significant difference (respectively, p=0.96, p=0.87, p=0.12, p=0.23, p=0.17). Besides, there was no significant difference between two groups in terms of the ratio of cardiac causes of death,too(p=0.21). Conclusion: In this study, it was shown that there was no significant difference between the ratio of cardiac death and Cardiology and/ or Emergency department admission with cardiac complaints between patients with AD using AChEIs and those not using.
Keywords: Alzheimer’s disease, acetylcholinesterase inhibitors, myocardial infarction, bradycardia, angina pectoris, mortality.
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