EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HOMOLOGY MODELING AND INSILICO ANALYSIS OF PROTEINS OF BOMBYX MORI - “A GREEN APPROACH”

Aashika A., Rubalakshmi G.*, Nirubama K. and Prabhakaran S.

ABSTRACT

Sericin is a natural polymer produced by Silkworm also known as Bombyx mori. The Silk worm wounds around itself a fiber, cocoon which keeps together two fibroin filaments. The fibrion forms central core and sericin forms envelop and is water soluble. In this present study, 10 proteins of Sericin were analysed using bioinformatics tools. Structural prediction and functional characterization of proteins of Sericin were done using Expasy Protparam server, 3D structure was done using SWISS MODEL. Plants of different family showing identity 30% and above were selected and its sequences retrieved, aligned using Clustal Omega. Phylogenetic tree was constructed for the aligned sequence. Structure prediction showed that α – helix, random coil, β – turn and extended strand predominates. Transmembrane region was found in NADPH cytochrome P450 reductase, cytochrome c oxidase subunit 1, nicotonic acetylcholine receptor proteins. NADPH cytochrome P450 reductase possesses the abilty to reduce metals and hence Sericin was predicted for its ability to synthesis nanoparticles. Phylogenetic analysis of NADPH cytochrome P450 reductase of sericin reveals that the Bombycidae families are closely related. Thus, sericin is a potential biocompatible material for its biomedical applications.

Keywords: Bombyx mori, NADPH cytochrome P450 reductase, sericin, Phylogenetic analysis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )