( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Tony M. Kuriakose* and Dr. Arun Raj R.


The present study aims at formulation, optimization and characterization of floating Poly Methyl Methacrylate (PMMA) microspheres of Baclofen and Rabeprazole sodium and to formulate into a bilayer tablet for the management of multiple sclerosis and persistent hiccups. Here, both the drugs are having short biological half-life which limits their therapeutic potential. Gastro Retentive Floating Drug Delivery System is used for increasing gastric residence time of the drugs. Due to its high biocompatibility, PMMA is a widely used polymer. Baclofen and Rabeprazole sodium microspheres were prepared separately by o/w solvent evaporation method. The prepared microspheres of baclofen and rabeprazole sodium were characterized forits percentage entrapment efficiency, percentagebuoyancy, percentage in-vitro drug release profile, Scanning electron microscopy study and differential scanning calorimetry. Nine formulations each of baclofen (FB1-FB9) and rabeprazole sodium (FR1-FR9) floating microspheres were prepared according to the response surface 3 level factorial design by Design expert 11 trial version. Based on statistical evaluation of Software suggested one optimum batch each for Baclofen and rabeprazole sodium floating PMMA microspheres. The Optimized microspheres of baclofen and rabeprazole sodium were evaluated and formulated into bilayer tablet by direct compression. Sustained release layer of baclofen showed an in-vitro drug release of 77.4% and that of rabeprazole sodium exhibited an in-vitro drug release of 79.7% in 0.1N HCl at the end of 8th hour in-vitro dissolution study. In-vivo floating study of the formulated bilayer tablet was performed in New Zealand rabbit for 6 hours and was well retained in the stomach.

Keywords: Baclofen, Rabeprazole sodium, Floating PMMA microspheres, Bilayer tablet, Multiple sclerosis, Persistent hiccups.

[Full Text Article]



  • New Issue Published

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )