A STUDY OF CLINICAL PROFILE OF DENGUE PATIENTS WITH SPECIAL REFERENCE TO HEPATIC DYSFUNCTION IN A TERTIARY CARE HOSPITAL IN NORTH KARNATAKA
*Dr. Khwaja M. Mohsin, Dr. M.V. Kalasuramath and Dr. Smrthi Shetty
ABSTRACT
Background: Dengue is a globally important arboviral infection transmitted by Aedes mosquitoes that endangers an estimated 2.5 billion people and represents a rapidly growing public health problem. There are between 50 and 100 million infections each year, with approximately 500,000 cases admitted to hospital with severe and potentially life threatening disease.[1] In our prospective study, 100 consecutive cases of dengue patients were studied. Patient underwent detailed clinical evaluation followed by laboratory investigations with special reference to hepatic dysfunction. Results: Male to female ratio was 2.3:1. Majority of the cases having dengue infection belong to the age group of 15-30 years. All the cases had fever (100%). Next common symptom in our study being vomiting (39%), headache (26%), abdominal pain (25%) and joint pain (20%). In our study, 32% clinically had hepatomegaly. Nearly 93% of the patients had thrombocytopenia. About 95% had deranged SGOT levels of which 22% had two and three times the normal range and 51% had more than three times the normal. Also 87% patients had deranged SGPT of which 41% and 21% had two and three times the normal levels and 25% had more than three times the normal level Conclusion: In adult patients with dengue infection, hepatic injury is nearly universal. Although in large majority of the patients it is asymptomatic, in some patients, it leads to clinical manifestations of liver disease keywords – Dengue, Hepatic dysfunction, Thrombocytopenia.
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