EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CAN ANGIOPOIETIN-1 DIFFERENTIATE BETWEEN SIGNIFICANT AND NON-SIGNIFICANT FIBROSIS IN CHRONIC HEPATITIS C PATIENTS?

Gamal E. Shiha*, EL-Shahat A. Toson, Ahmed E. Amin, Reham E. Soliman and Mohamed T. Ali

ABSTRACT

Background: The assessment of liver fibrosis by non-invasive methods is clinically important where hepatitis C virus (HCV) is common in Egypt. The aim is to assess the ability of Angiopoietin-1(Ang-1) as a direct marker to differentiate between significant and non-significant fibrosis Method: Blood samples were collected from 120 CHC patients (F0-F4). Ang-1 serum levels were assayed using an enzyme-linked immunosorbent assay, HCV RNA and HCV antibodies, liver function tests and platelet counts; beside, liver biopsy were evaluated. The numerical value of the AAR was calculated. Then, the diagnostic performance of Ang-1 was compared with the latter score; at their original cut-off. Results: Ang-1 can efficiently differentiate patients with non-significant (F0, F1) from those with significant fibrosis (F2–F4) with sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and of AUC of 89, 91, 89, 91 and 0.919, respectively. Conclusions: Ang-1 can help in assessing hepatic fibrosis and superior to AAR score in discriminating the stages of the liver disorders in CHC Egyptian patients.

Keywords: Angiopoietin-1, diagnostic performance, Liver fibrosis, Hepatitis C virus.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )