SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A NOVEL APPROACH TO ENHANCE THE ORAL BIOAVAILABILITY OF LIPOPHILIC DRUGS

*Shubhangi Jagannath Patil, Shubhangi Amarsingh Patil, Rinku Yogesh Patil and Shagufta Juber Pathan

ABSTRACT

Now days the present scenario is focusing more towards the targeted drug delivery systems because of the increasing interest in taking of safe drugs with less amount of drug, which is capable of reaching at the desired target site with minimal side effects. Novel drug delivery system has been introduced to overcome the drawback of fluctuating drug levels associated with conventional dosage forms.[1] Approximately 40% of new drug candidates have poor water solubility and the oral delivery of such drugs is frequently associated with low bioavailability, high intra- and inter-subject variability, and a lack of dose proportionality.[1] To overcome these problems, various formulation strategies are exploited including the use of surfactants, lipids, permeation enhancers, micronisation, salt formation, cyclodextrins, nanoparticles and solid dispersions.[1] Recently, much attention has been paid to lipid-based formulations with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS) to improve the oral bioavailability of lipophilic drugs.[2, 3]

Keywords: SMEDDS, Drug targeting, Evaluation, Applications.