EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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 ICV - 79.57

Abstract

INHIBITORY EFFECT OF COLCHICINE ON VASCULAR SMOOTH MUSCLE CELL PROLIFERATION INDUCED BY PLATELET-DERIVED GROWTH FACTOR-BB

Sook Nam Park, MS, Man Kyu Huh, PhD and Yong Lim*, PhD

ABSTRACT

Abnormal proliferation of rat aortic vascular smooth muscle cells (VSMCs) is thought to play an important role in the pathogenesis of atherosclerosis and restenosis. The aim of this study was to elucidate the antiproliferative effects and molecular mechanism of colchicine on platelet-derived growth factor (PDGF)-BB-stimulated rat aortic vascular smooth muscle cells (VSMCs). Antiproliferative effects of colchicine on rat aortic VSMCs were examined by direct cell counting and by using [3H] thymidine incorporation assays. It was found that colchicine potently the growth of VSMCs. Pre-incubation with colchicine (0.1∼10 μM) significantly inhibited proliferation. In accordance with these findings, colchicine blocked the PDGF-BB induced progression of synchronized cells through the G0/G1 phase of the cell cycle. Whereas, colchicine did not show any cytotoxicity in rat aortic VSMCs in this experimental condition by CCK-8 assay. Colchicine inhibited the PDGF-BB-stimulated phosphorylation of p38. Colchicine also inhibited the proliferating cell nuclear antigen (PCNA), a key regulator in the cell cycle. These findings suggest that the inhibition of colchicine to the cell proliferation. In conclusion, colchicine may be a potential anti-proliferative agent for the treatment of atherosclerosis and angioplasty restenosis.

Keywords: Antiproliferative effects, Colchicine, Platelet-derived growth factor (PDGF)-BB, Vascular smooth muscle cells (VSMCs).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia