EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

IN SILICO DOCKING AND IN VITRO ENZYME INHIBITION ACTIVITY OF UNRIPE FRUITS OF FICUS RACEMOSA LINN

P. G. Muralikrishna*, Dr. B. Duraiswamy and Nair N. K.

ABSTRACT

Ficus racemosa, a versatile medicinal plant, is investigated for many biological activities. The plant is a unique source of various types of compounds having diverse chemical structures. The ethnobotanical and reported studies says it is indicated in hyperglycemia and diabetes. In this study it evaluates relationship between various reported terpenoids in fruit of plant and the targeted protein relating to diabetes in human, it involved docking of 3D structures of ligand (compounds) to selected targeted proteins. The in silico docking studies confirmed that the terpenoid contents in the fruit is having good interaction to the specific target proteins, among the terpenoids, the 2 compounds, viz. beta sitosterol and Friedelin are having pronounced docking and interaction with receptors 2QMJ and 2V95 the hyperglycemic targets. In invitro enzyme inhibition studies the extracts of unripe fruits of Ficus racemosa was tested to understand the antihyperglycemic potential. Both extracts were found to inhibit enzymes considerably.The methanol extract showed maximum inhibitory activity with alpha amylase enzyme, whereas aqueous extract signaled a maximum inhibitory action with alpha glucosidase enzyme. Docking study and enzyme inhibition data reveals potent implication of unripe fruits of Ficus racemosa in Hyperglycemia and Diabetes.

Keywords: Hyperglycemia, Ficus racemosa, docking, diabetes mellitus, enzyme inhibition, receptors.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia