THE MEANING OF TWO LOCI HLA CLASS II HAPLOTYPES DISTRIBUTION IN CHRONIC GLOMERULONEPHRITIS AND CHRONIC KIDNEY DISEASE IN UZBEK POPULATION

Ruzibakieva Malika Ruslanovna, Aripova Tamara, Kasimov Abdumadjid, Yuldashev Ulugbek

ABSTRACT

End-Stage Renal Disease (ESRD) is a worldwide public health problem. There are many studies have found the association between human leukocyte antigen (HLA) and glomerulonephritis. As it is well known, big role in the disease progression plays single alleles, but some times more important role are playing there allelic combinations from different HLA loci. The aim of this study was to find out if there are any two-loci haplotypes are playing role in the development of glomerulonephritis and ESRD in Uzbek patients.

Keywords: Chronic kidney disease, End Stage Renal Disease, HLA.