ENHANCEMENT OF BIOAVAILABILITY OF IBUPROFEN BY USING SOLID DISPERSION TECHNIQUE

Mali Alpesh Mahadeo*, Ghodake Ganesh, Gharge Varsha

ABSTRACT

In this study of Ibuprofen it is an (NSAIDs) non steroidal anti- inflammatory drug and used as analgesic & anti –inflammatory drug. It can be also used in the treatment of rheumatoid arthritis, osteoarthritis, and primary dysmenorrheal. Ibuprofen is absorbed rapidly, bound avidly to protein, but it has low aqueous solubility so it also lowers the dissolution profile of drug. To overcome this problem, various techniques are used, like solid dispersion, complexation, co-solvency, hydro trophy. nano- technology approach. In this study, the dissolution rate of poorly soluble drug was increased by preparing solid dispersion with PEG-4000 in ratio of (1:1), (1:3) &,(1:5) by using melt dispersion and solvent evaporation method. The rate of dissolution was increased with the proportion of (1:5) when compared to the other formulations.

Keywords: Ibuprofen, PEG-4000, PVP k30,Solid dispersion, Dissolution Rate.