STUDY ABOUT BIOCHEMICAL AND IMMUNOLOGICAL CHANGES DURING HYPOVOLEMIC SHOCK

Sona Kaushal Bharti and Rangeel Singh Raina*

ABSTRACT

Objective: To evaluate biochemical parameters and their clinical implications with their ability to predict the course of shock. Materials & Methods: This prospective study evaluate various changes in the biochemical parameters and there clinical relationship in predicating the nature, gravity and possible outcome of the shock. Results: Blood sugar, urea levels were found to be raised in severe hypotension in most of patients. Protein levels were in the normal range though on the lower side. Hypokalemia was seen in all the subgroups of shock. Serum lactate continued to remain high in majority of the cases. IgA and IgG levels remained normal throughout the study period whereas lgM levels remained persistently higher in almost all the patients. Complement C3 was lower than the normal levels in all the groups whereas Complement C4 was below normal level in only severe case. In severe cases of shock pH ranged above than the normal levels and then tends to recover towards normal range. Saturation of oxygen was below normal levels in severe hypotension patients which recovered with treatment on day five of hospitalization. Conclusion: It can be concluded that the clinical monitoring and judgment associated with biochemical monitoring are the best parameters available.

Keywords: hypovolemia, biochemical parameters, inadequate perfusion.