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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Archibong N. Archibong, Solomon A. Leilei, Akaninyene U. Ime*, Joffa P. Kwaku and Mobisson S. Kelechi


Dietary periwinkle (Tympanotonus fuscatus) is natural seafood with very rich vitamins and nutrients, but there is little or no literature on its effect on different biomarkers of liver function, hence the need for this study. Twenty one albino Wistar rats weighing between 200-250g were assigned into 3 groups of 7 rats each, housed singly in metabolic cages. Rats in control group took normal rat pellet and drinking water ad libitum. The 2 test groups were administered two different doses (low dose (7.0mg/kg b. w) and high dose (52mg/kg b. w) of periwinkle extract. At the end of six weeks feeding period, blood samples were obtained from all the rats via cardiac puncture for biochemical analysis. The liver was also harvested for histological study. The result of the analysis showed that rats placed on both the low and high doses of the extract had significant increases in total protein (p<0.001) and globulin (p<0.001) compared with control group. The extract fed rats also had significantly reduced ALT (P<0.001) and ALP (P<0.001) levels compared with the control. The extract had no effect on the cytoarchitecture of the liver. This study has therefore revealed that consumption of Tympanotonus fuscatus has no adverse effect on health but rather offers a protection, as reflected by the result of the serum protein, serum enzyme and even the histological studies. In conclusion, dietary periwinkle (Tympanotonus fuscatus) extract has hepato-protective potentials and its consumption should therefore be encouraged.

Keywords: Periwinkle, Liver, Enzymes, Proteins, Omega 3 fatty acid.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia