( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Herve Tchoumbou Tadjoua*, Gilbert Ateufack, William Nana Yousseu, Olivette Laure Matafack Dongmo, Simjee Usman Shabana, Donatien Gatsing and Choudhary Iqbal Muhammad


Background: In Africa, principally in Cameroon, the aqueous extract of Dissotis thollonii is traditionally used for the diarrhoeal and inflammatory diseases. However, no scientific study was used to evaluate the safety of its use. This study aim to assess the anti-diarrheal and anti-inflammatory activities of the plant extracts on rats and mice. Methods: anti-diarrheal activity was studied on induced diarrheal by castor oil and intestinal motility in rat. In vivo anti-inflammatory effect was study using carrageenan induced peritonitis in mice. ROS production from phagocytes, TNF-α, antiproliferative activity on HeLa cell lines and cytotoxic activity were performed by using chemiluminescence technique. Results: The results indicated that aqueous and methanolic leaves extracts of Dissotis thollonii had, after 6h of observation, significantly (p<0.001) inhibited curatively diarrhoea induced experimentally by castor oil by increasing the latency time and reducing the frequency of defecation and water content at all the doses, compared to negative control which received distilled water. These extracts also reduced peristaltic movement in castor oil-induced intestinal transit. Results were also compared with loperamide used as anti-diarrheal drug. Additionally, Dissotis thollonii decreased significantly the number of leukocytes migration in peritoneal fluid in vivo, and in vitro, inhibited significantly (p< 0.001) the intracellular ROS production. Dissotis thollonii also possess significant (p< 0.001) inhibitory effect on the proliferation of Hela cell lines, on the reduction of TNF-α production and showed a brine shrimp larvicidal activity. Conclusions: Dissotis thollonii show anti-diarrheal and anti-inflammatory properties in rats and mice respectively, and anti proliferative activity in vitro. The results confirm traditional use of Dissotis thollonii in Cameroon concerning the treatment of diarrhea and inflammation.

Keywords: Dissotis thollonii, Anti-diarrheal, Anti-inflammatory, cytotoxicity.

[Full Text Article] [Download Certificate]


  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 June 2024 Issue has been Published, Kindly check it on


    JUNE 2024 issue has been successfully launched on JUNE 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia