ORODISPERSIBLE LIQUISOLID COMPACTS: A NOVEL APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY

Rajalakshmi A.N*, Vinoth Kumar. P, Stephen. P 

ABSTRACT

The oral route remains the preferred route of drug administration due to its convenience, good patient compliance and low production costs. In order for a drug to be absorbed into the systemic circulation following oral administration, the drug must be dissolved in the gastric fluids. For hydrophobic drugs, the dissolution process acts as the rate-controlling step and which determines the rate and degree of absorption. Bioavailability of poorly water soluble drugs is limited by their solubility and dissolution rate.

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