EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AN OVERVIEW ON LEUKODYSTROPHY-A RARE BRAIN DISORDER

Wasfiya Noor Syeda*, Asra Ali Bahazeq, MD. Muzaffar-Ur-Rehman, Fariya Nimrana and Ayesha Mateen

ABSTRACT

Leukodystrophy is a group of metabolic and progressive disorder that genetically affects the central nervous system of the human body. Leukodystrophies are caused by abnormal development or destruction of the myelin sheath of the brain which is caused due to the specific gene abnormality. The lifespan of the patients depends on the age at which they are first diagnosed. The disease progresses more quickly when it is diagnosed at an early age. Currently, there is no cure for the leukodystrophies but stem cell therapy and bone marrow transplantation have each been tried in some cases and found to be successful. The benefits of transplant however, depend on the timing, age of onset and severity of symptoms. The damage caused to the white matter can lead to inflammation in the CNS, along with loss of myelin. The white matter destruction can be observed and leukodystrophy is diagnosed by MRI scanning. Leukodystrophy is generally characterized by specific symptoms including decreased motor function (inability to walk), muscle rigidity, and eventually degeneration of sight and hearing. Leukodystrophies has combined incidence and is estimated 1 in 7,600 of population. The inheritance of a recessive, dominant, or X-linked trait are involved while others, although involving a defective gene, are the result of spontaneous mutation rather than genetic inheritance. To study the cellular processes of myelination many research groups are implemented which provides insights into leukodystrophy and its related disorders. Researchers in New York have cured leukodystrophy successfully in mice, using skin cells to repair damaged myelin sheaths of the central nervous system.

Keywords: Leukodytrophy, myelination, demyelination, diagnosis, treatment.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )