NANOEMULSION BASED DRUG DELIVERY-A REVIEW

Sunny Chaudhary, Navneet Kumar Verma*, Prabhudutta Panda, Abhay Pratap Singh, Gulzar Alam

ABSTRACT

Nanoemulsions are submicron sized emulsion that is under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Nanoemulsions have the potential in pharmaceutical industries because of the transparency at high droplet volume fraction, higher rate of bioavailability or diffusion and increased shelf life of the pharmaceuticals. Nanoemulsions are clear, thermodynamically stable, isotropic liquid mixtures of oil, water, surfactant and co-surfactant. These are oil-in-water (o/w) type of emulsions with the average droplet size ranging from 5nm to 100 nm. Reduction in droplet size to nanoscale leads to change in physical properties such as optical transparency & unusual elastic behavior. Thus the aim of this review is focused on nanoemulison advantage and disadvantage, various methods of preparation, characterization techniques and the various applications of sub micron size emulsion in different areas such as various route of administration, in chemotherapy, in cosmetic, etc.

Keywords: Nanoemulsion Submicron size droplet Self emulsifying agent Drug delivery system.