ANTIOXIDANT MICRONUTRIENTS AND HEMATOLOGICAL INDICES OF DIABETIC ISCHEMIC STROKE SUBJECTS

Wali U., Yusuf S., Suleiman A. I., Balarabe S. A.*, Bilbis L. S. and Sahabi D. M.

ABSTRACT

Diabetic Ischemic stroke (DIS) is characterized by elevated level of oxidative stress indices, declined antioxidant defenses and hematological impairment. Increased oxidative stress is thought to play a role in the development of DIS and its attendant complications. We investigated serum fasting blood sugar (FBS), malondialdehyde (MDA), Special enzymes such as superoxide dismutase (SOD), glutatuione peroxidase (GPx), Catalase (CAT), Vitamins (A, C, and E), Cu, Cr, Zn, Mn and Se, Rbc counts, Hb, Wbc counts and platelet counts and BP of 37 diabetic Ischemic strokes (DIS) attending Neurology clinic of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the results compared with 42 non-diabetic ischemic stroke (NDIS) subjects. The results suggested significant increased (P<0.05) levels of FBS, MDA and non significant increase (P>0.05) of BP, Wbc counts, Rbc counts and platelet counts and decreased levels of antioxidant enzymes (SOD, GPx and CAT), Vitamins (A, C, and E), minerals (Cu, Cr, Zn, Mn and Se),RBC, counts and Hb in diabetic Ischemic strokes subjects compared with non-diabetic Ischemic stroke subjects. It is concluded that diabetic Ischemic strokes in the study area contribute to depletion of antioxidant defense mechanism and impaired hematological Indices, an indication that the diabetic Ischemic stroke patients are predisposed to increased oxidative onslaught.

Keywords: Antioxidants, Diabetic Ischaemic stroke, oxidative stress micronutrients hematological Indices.