EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

PROCESS CONTROL AND MEDIUM FORMULATION FOR INDUSTRIAL FERMENTATION

Sikander Ali, Rabia Akram, Shahbaz Tariq*, Faiza Riaz and Syeda Fatima Nadeem

ABSTRACT

Fermenter control and media formulation has been a dynamic area of research and it captivated the attention of world. All this is because of the new advances in other interrelated areas which may be utilized to overcome the inherent complications in control of fermenter. Organization with conventional dictatorial control of variables such as pH, temperature and dissolved oxygen concentration, research in control of fermenter has undergone important changes including the current neural network based methods. At industrial scale fermentation, media are required for growth of specific microbes in a fermenter. Thus fermenter control, nutrients availability and fermentation efficiency, all are important factors in medium formulation process. The microorganisms used for process of fermentation grow in specially designed medium having appropriate supply of nutrients such as sources of nitrogen and carbon, energy sources, certain mineral elements, and water and perhaps vitamins plus oxygen in case of aerobic nature of microbes. Trace nutrients and growth factors are also important for microbes which are incapable of fulfilling their nutrient requirements. Trace elements including copper, zinc, cobalt, molybdenum, iron and manganese are added to medium when purified nitrogen and carbon sources are used. Phosphates and carbonates are used as mineral buffering salts to stabilize pH and antifoaming agents are used to prevent foam formation during fermentation process. Chelating agents are also used at higher concentrations of metal ions. There should be perfection in organism selection and correctness in medium formulation for large scale production of particular product. Although complete analysis is necessary to develop a suitable medium for fermentation process.

Keywords: fermenter, fermentation, media, nutrients, microbes, aerobic, variables, trace elements, growth factors, chelating agents, antifoaming agents.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia