BIOFILM PRODUCTION AND ANTIBIOTIC RESISTANCE

Maurice Mbah*, Nyong, Doreen Mmaette Michael, Samuel Akpan, Inyang ,Imeobong Joseph

ABSTRACT

Biofilms are structured communities of microorganisms attached to a surface. Microorganisms such as bacteria, algae, fungi, protozoa may be found in a biofilm consortium attached to biological or non-biological surfaces. Their formation starts from initial attachment to their dispersal to other surfaces where they colonize and sometime cause infections especially on biological surfaces like living tissues and medical devices, which is of great importance to public health. Cells in the biofilm assemblage communicate through quorum sensing, affecting biofilm processes like cell detachment and exchange of genetic materials. Biofilms cause slow and persistent infections which interfere with antibiotic therapy. They are also a major concern in food industries, oil industries and aquaculture. To assay biofilms, methods like Tissue culture plate method, tube method and Congo red agar method can be used. Chemical, physical and biological methods are being used to control biofilms. A greater understanding of biofilm processes will lead to novel and effective strategies for biofilm control and a resulting improvement in patient management, enhancing the clinical decision-making process.

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