FUNGAL INFECTION AND THE ROLE OF LEPTADENIA HASTATA (PER) DECNE.

Isaac John Umaru*, Fasihuddin A. Badruddin, Zaini B. Assim, and Hauwa A. Umaru

ABSTRACT

Fungal infections (mycoses) are likely to occur more frequently as ever-increasingly sophisticated healthcare systems create greater risk factors, the limited access to more powerful diagnostic tools and agents for fungal infection, there is a paucity of data and drugs regarding the burden of fungal infections in the world. The main objective of this study was thus to study the fungal infection and the role of Leptadenia hastata Stem-bark overcome the burden of severe fungal infections in the world thus establishing reasonable agents to fight the incidence and prevalence’s. Material and method; the fungal activities of the extract at various concentration were performed by agar diffusion method, DMSO as negative control while Fluconazole as positive control for five days. One-way ANOVA was used to determine the statistical difference between three mean inhibition value at significance P<0.005. Result: The concentration of extract at days four and five, 25ppm, 50ppm and 100ppm showed the highest activities against Aspergillus flavus, Aspergillus niger, Candida tropicallis, and Fusarium oxysporium was very significant when compared with the control drug. Conclusion; The results of investigation indicate significant inhibition to reduce the burden of human fungal infections in the world.

Keywords: Aspergillus flavus, Aspergillus niger, Candida tropicallis, Fusarium oxyporium, Leptadenia Hastate.