EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

COMPARATIVE HEMATOLOGICAL EFFECTS OF CIMETIDINE, ASCORBIC ACID, CITRUS AURANTIFOLIA AND TETRACARPIDIUM CONOPHORIUM IN ADULT MALE ALBINO WISTAR RATS

Elizabeth Okokon Enodien, Okon Uduak Akpan and Idiongo Okon Umoh*

ABSTRACT

The day-to-day use of Cimetidine, Vitamin C, consumption of Lime and Walnuts increases globally with its rapid social and medicinal acceptance by both genders. In view of their wide usage especially in Africa, it becomes necessary to ascertain its comparative effects on haematological parameters of male albino wistar rats. Thus to study the effects of cimetidine, ascorbic acid (Vit. C), Citrus aurantifolia (lime) and Tetracarpidium conophorium (walnut) on haematological parameters, ninety six male albino wistar rats weighing 154 g - 281 g were obtained and divided into six groups. Groups A-D had 18 animals per group while Groups E and F had 12 animals each. Groups A-D were further divided into three sub-groups each of six animals per group with sub-group1 as control group, sub-group2 and 3 as experimental groups treated with medium and high doses of cimetidine, Vitamin C, Lime and walnut respectively. Group E and F were divided into two sub-groups of six animals each with sub-group1 as control and sub-group2 as experimental group treated with combined medium doses of cimetidine + Vitamin C and lime + walnut respectively. Administration was done twice daily for 21 days. At the end of the treatment period, blood samples were obtained and analysed for haematological investigation. The results revealed that Cimetidine significantly reduced (p<0.05) WBC, RBC and PCV in medium dose groups compared to control. Lime significant decreased (p<0.05) WBC in medium dose group and Hb in medium and high dose groups compared to control. Combination treatment of Cimetidine and Vitamin C significantly decreased (p<0.05) WBC compared to control. Conclusively, cimetidine and lime interferes with haematopoiesis, Vitamin C has no effect on blood meanwhile Walnut plays a role in blood pressure regulation.

Keywords: Cimetidine Hematological indices, Citrus aurantifolia, haematopoiesis, Tetracarpidium conophorium.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia